Prof. Arie Admon

Courses

Research Interest

Publications

 

Associate professor of biology.
Arie Admon is the head of the The Smoler Proteomics Center at the Technion
Department of Biology
Technion - Israel Institute of Technology
Haifa 32000, Israel
Tel: 04-8293407 (Office), 8293446 (Proteomics Center), 8293691 (Lab)
Fax: 04-8225153
admon@tx.technion.ac.il
 

 

Courses:

Biochemistry A 134044

Biochemistry L 134048

Proteomics 138018

Research Interest:

Smoler Proteomics Center. Prof. A. Admon heads the Smoler Proteomics Center at the Department of Biology, Technion. The Smoler Proteomics Center gained national recognition and has been expanded into a National "open" Center for proteomics, which was funded by the Ministry of Sciences and Arts. The main thrust of the Smoler Proteomics Center is of microanalysis of protein and peptides on a large scale, now known as proteomics analysis. Main instruments are: HPLCs, 1D, 2D electrophoresis and mass-spectrometry with one MALDI-TOF-TOF, two ESI-ion traps and one Q-TOF.

Tumor specific MHC restricted peptides. Direct biochemical analysis of cancer cell MHC restricted peptides presented on human cancer cells. We perform direct analysis by LC-mass-spectrometry of human cancer MHC class I peptides antigens in order to develop anti-cancer vaccine for human immunotherapy. The main focus peptides specific for small cell lung cancer, ovarian, breast and prostate cancers. The analysis is based mostly on the use of soluble MHC secreted from cancer cells following their transfection with expression vectors for the extra cellular part of the MHC molecules

Pep-Miner a new protein identification and comparison bioinformatics platform developed at the IBM Haifa Research Laboratory by Mr. Ilan Beer.

Selected Publications:

 Barnea, E., Beer I, Patuka R., Ziv T. and A. Admon. (2001) Comprehensive analysis of MHC class I peptide antigens from cancer cells by mass spectrometry. Proceedings of the 49th American Society for Mass spectrometry conference.

Barnea E., Beer I., Patoka R., Ziv T., Kessler O., Tzehoval E., Eisenbach L., Zavazava N. and A. Admon. Analysis of endogenous peptides bound by soluble MHC class I molecules: A novel approach for identifying tumor specific antigens. Eur. J. Immunol. (2002) 32, 213-222.

Herschhorn, A., A. Admon, and A. Hizi, Recombinant human antibodies against the reverse transcriptase of human immunodeficiency virus type-1. (2003) Biochim Biophys Acta, 1648, 154-63.

Buchsbaum, S., E. Barnea, L. Dassau, I. Beer, E. Milner, and A. Admon, Large-scale analysis of HLA peptides presented by HLA-Cw4. (2003) Immunogenetics, 55, 172-

Wolff, N., Cogan, U., Admon, A., Dalal, I., Katz, Y., Hodos, N., Karin, N. and Yannai, S. (2003) Allergy to sesame in humans is associated primarily with IgE antibody to a 14 kDa 2S albumin precursor. Food Chem Toxicol, 41, 1165-74.

Beer I, Barnea E, Ziv T. and A. Admon. Improving Large-Scale Proteomics by Clustering of Mass Spectrometry Data. (2004) Proteomics 4, 950-60.

Burger, O., Pick, E., Zwickel, J., Klayman, M., Meiri, H., Slotky, R., Mandel, S., Rabinovitch, L., Paltieli, Y., Admon, A. and Gonen, R. Placental protein 13 (PP-13): effects on cultured trophoblasts, and its detection in human body fluids in normal and pathological pregnancies. (2004)  Placenta, 25, 608-22.

Berg M., Barnea E., Admon A. and N. Zavazava. A novel DNA Methyl transferase I-derived peptide eluted from ALA-A0201 induces peptide-specific tumor directed cytotoxic T cells. Int J Cancer. (2004)112, 426-432.

Admon, A., E. Barnea, and T. Ziv, Tumor antigens and proteomics from the point of view of the major histocompatibility complex peptides. Mol Cell Proteomics, 2003, 2, 388-98.

Shoshan, S.H. and A. Admon MHC-bound antigens and proteomics for novel target discovery. Pharmacogenomics. (2004) 7, 845-59.



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